The CD41 Rabbit Monoclonal Antibody is a highly specific and sensitive tool for researchers studying CD41, a glycoprotein found on the surface of platelets and megakaryocytes. This antibody, produced in rabbits, has been rigorously validated for use in a variety of applications, including immunohistochemistry, flow cytometry, and immunofluorescence.CD41, also known as Integrin alpha 2b, plays a crucial role in platelet aggregation and is essential for normal hemostasis. Dysregulation of CD41 has been implicated in various bleeding disorders and thrombotic diseases, making it a valuable target for research in the fields of hematology and cardiovascular medicine.
By using the CD41 Rabbit Monoclonal Antibody, researchers can accurately detect and analyze CD41 expression in different cell types and tissues, providing valuable insights into the role of this protein in normal physiology and disease states. Its high specificity and sensitivity make it an ideal tool for studying platelet function and developing new therapies for thrombotic and bleeding disorders. Order now to advance your research in hematology and cardiovascular medicine.
Product Name:
CD41/ITGA2B Rabbit Monoclonal Antibody
SKU:
CAB11490
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CD41/ITGA2B (P08514).
This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia.
Purification Method:
Affinity purification
Gene ID:
3674
Clone Number:
ARC0620
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD41/ITGA2B Rabbit mAb (CAB11490) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
