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CD41 monoclonal antibody (APC) (AGIM0472)

SKU:
AGIM0472
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
TR8
Conjugation:
APC
Applications:
FC
$215
Frequently bought together:

Description

system_update_altDatasheet
Product Name:CD41 monoclonal antibody (APC)
Product Code:AGIM0472
Size:100 µL
Reactivity:Human
Clone:TR8
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Do not freeze. Avoid prolonged exposure to light.
Background:CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, ?± and 23 kDa b, ??) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is noncovalently associated with CD61 (GPIIIa) to form the GPIIb/IIIa (CD41/CD61) complex. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. The CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage and acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, vitronectin, thrombin and mediates platelets aggregation. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation. The CD41/CD61 (GPIIb/IIIa) may be absent or strongly reduced in Glanzmann's thrombasthenia (GT).

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