The CD40 Polyclonal Antibody (CAB13285) is a valuable tool for researchers studying the CD40 protein, which plays a pivotal role in immune system function. This antibody, derived from rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding specifically to CD40, this antibody enables the accurate detection and analysis of the protein in various cell types, making it an essential component in immunology and cancer research studies.CD40 is a cell surface receptor protein that is essential for a range of immune responses, including B cell activation and antibody production.
It also plays a crucial role in regulating inflammation and shaping the immune system's response to pathogens. Given its involvement in various aspects of immune function, CD40 is an important target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By understanding the function of CD40, researchers can develop targeted therapies that modulate the immune response in these contexts, ultimately leading to advancements in treatment strategies.
Product Name:
CD40 Rabbit Polyclonal Antibody
SKU:
CAB13285
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-104 of CD40 (NP_001241.1).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
31kDa
Observed MW:
42kDa
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
958
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD40 Rabbit pAb (CAB13285) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
