The CD3D Polyclonal Antibody (CAB1238) is a valuable tool for researchers studying CD3D, a crucial component of the T-cell receptor complex involved in immune response regulation. This polyclonal antibody is raised in rabbits and has been validated for use in Western blot applications, showing high reactivity with human samples. By specifically binding to the CD3D protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in immunology, infectious diseases, and cancer research.CD3D is essential for T-cell activation and function, playing a crucial role in the adaptive immune response. Dysregulation of CD3D expression or function has been implicated in various diseases, including autoimmune disorders, immunodeficiency conditions, and certain types of cancer.
Research into the mechanisms underlying CD3D activity is essential for developing targeted therapies and immunotherapies to effectively modulate immune responses in these contexts.Overall, the CD3D Polyclonal Antibody (CAB1238) is a valuable tool for researchers seeking to elucidate the role of CD3D in immune regulation and disease pathogenesis. Its high specificity and reactivity make it a reliable option for studying the intricate mechanisms of T-cell activation and function in health and disease.
Product Name:
CD3D Rabbit Polyclonal Antibody
SKU:
CAB1238
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-105 of human CD3D (NP_000723.1).
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.
Purification Method:
Affinity purification
Gene ID:
915
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Jurkat cells, using CD3D Rabbit pAb (CAB1238) at 1:500 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
