The CD38 Polyclonal Antibody (CAB13611) is a valuable tool for researchers studying CD38, a cell surface molecule with key roles in immune response and inflammation regulation. Produced using rabbit immunization methods, this antibody has high reactivity with human samples and has been extensively validated for Western blot applications.CD38, a multifunctional enzyme involved in cell signaling and immune regulation, is a promising target for research in immunology, oncology, and autoimmune diseases. By detecting and analyzing CD38 protein levels in various cell types, this antibody enables researchers to gain insights into its functions and potential therapeutic implications.
With its ability to specifically bind to CD38, this polyclonal antibody is essential for studies aiming to understand the role of CD38 in immune responses and its implications in diseases like cancer and autoimmune disorders. Its reliability and versatility make it an essential tool for advancing knowledge in these fields and developing targeted therapies for immune-related conditions.
Product Name:
CD38 Rabbit Polyclonal Antibody
SKU:
CAB13611
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 43-300 of human CD38 (NP_001766.2).
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
952
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD38 Rabbit pAb (CAB13611) at 1:2000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Enhanced Kit (AbGn00021).Negative control (NC): Hep G2.Exposuretime: 30s.
