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CD36/SR-B3 Polyclonal Antibody

SKU:
CAB21716
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
$155 - $431
Frequently bought together:

Description

CD36/SR-B3 Polyclonal Antibody (CAB21716)

The CD36 (SR-B3) Polyclonal Antibody is a valuable tool for researchers studying CD36, a cell surface receptor known for its role in lipid metabolism and inflammation. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting CD36 in human samples, making it ideal for use in various research applications such as Western blotting.CD36, also known as scavenger receptor class B member 3 (SR-B3), is involved in lipid uptake, lipid storage, and inflammation regulation in various cell types, including macrophages and endothelial cells. Dysregulation of CD36 has been linked to a variety of diseases, including atherosclerosis, diabetes, and cancer.

Therefore, studying CD36 expression and function is critical for understanding its involvement in these pathologies and potentially identifying therapeutic targets.By using the CD36 Polyclonal Antibody, researchers can accurately detect and analyze CD36 expression levels in different cell types and tissues, providing valuable insights into its biological functions and potential implications in disease progression. This antibody is a valuable tool for immunology, lipid metabolism, and inflammation research, offering researchers the ability to investigate the role of CD36 in various physiological and pathological processes.

Product Name:CD36/SR-B3 Polyclonal Antibody
Product Code:CAB21716
Reactivity:Mouse, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Mouse, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Positive Samples:Mouse heart, Rat heart
Cellular Location:Cell membrane, Multi-pass membrane protein

The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 93-165 of CD36/SR-B3 (NP_000063.2).
Sequence:FEPSL SVGTE ADNFT VLNLA VAAAS HIYQN QFVQM ILNSL INKSK SSMFQ VRTLR ELLWG YRDPF LSLVP YPV
Synonyms:FAT, GP4, GP3B, GPIV, CHDS7, PASIV, SCARB3, BDPLT10
Calculated MW:53kDa
Observed MW:70-110kDa

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