The CD36 Polyclonal Antibody (CAB1470) is a valuable tool for researchers studying the CD36 molecule, a cell surface receptor involved in various biological processes such as lipid metabolism, fatty acid uptake, and inflammation. This antibody, generated in rabbits, exhibits high specificity towards human samples and is validated for use in Western blot applications.CD36, also known as scavenger receptor class B member 3 (SR-B3), is a multifunctional protein that plays a crucial role in lipid metabolism and cardiovascular diseases. Its involvement in lipid uptake and atherosclerosis makes it a promising target for studies in cardiovascular research and metabolic disorders.
The CD36 Polyclonal Antibody binds specifically to the CD36 protein, allowing researchers to detect and analyze its expression in different cell types and tissues. By understanding the function of CD36, researchers can gain insights into its role in lipid metabolism, inflammation, and cardiovascular health, potentially leading to the development of novel therapeutic strategies for diseases associated with dysregulated lipid metabolism.
Product Name:
CD36/SR-B3 Rabbit Polyclonal Antibody
SKU:
CAB1470
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 301-400 of human CD36/SR-B3 (NP_001120916.1).
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
948
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from U-937 cells using CD36/SR-B3 Rabbit pAb(CAB1470) at 1:700 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime:90s.
