| UniProt Protein Function: | CD34: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Belongs to the CD34 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q32 Cellular Component: intercellular bridge; integral to plasma membrane; lysosome; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; basal plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:sulfate binding; carbohydrate binding; transcription factor binding Biological Process: positive regulation of odontogenesis; regulation of immune response; negative regulation of nitric oxide biosynthetic process; glomerular filtration; cell motility involved in cell locomotion; negative regulation of blood coagulation; negative regulation of tumor necrosis factor production; signal transduction; positive regulation of interleukin-10 production; cell proliferation; cell-cell adhesion; positive regulation of angiogenesis; endothelial cell proliferation; regulation of blood pressure; tissue homeostasis; hemopoiesis; leukocyte migration |
| NCBI Summary: | The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P28906 |
| NCBI GenInfo Identifier: | 3183511 |
| NCBI Gene ID: | 947 |
| NCBI Accession: | P28906.2 |
| UniProt Secondary Accession: | P28906,Q15970, Q15971, Q5JTA3, Q5JTA4, Q9UJB1, A8K664 |
| UniProt Related Accession: | P28906 |
| Molecular Weight: | 35,011 Da |
| NCBI Full Name: | Hematopoietic progenitor cell antigen CD34 |
| NCBI Synonym Full Names: | CD34 molecule |
| NCBI Official Symbol: | CD34Â Â |
| NCBI Protein Information: | hematopoietic progenitor cell antigen CD34; CD34 antigen |
| UniProt Protein Name: | Hematopoietic progenitor cell antigen CD34 |
| UniProt Synonym Protein Names: | CD_antigen: CD34 |
| Protein Family: | Hematopoietic progenitor cell antigen |
| UniProt Gene Name: | CD34Â Â |
| UniProt Entry Name: | CD34_HUMAN |
