The CD33 Polyclonal Antibody (CAB2059) is a vital tool for researchers studying CD33, a cell surface protein involved in immune regulation and cell signaling. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the CD33 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for use in immunology and cancer research studies.
CD33 is known to play a key role in immune response modulation, making it a significant target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By understanding the function of CD33, researchers can develop potential therapies that either enhance or inhibit immune responses in these disease contexts, providing valuable insights into immune regulation and potential treatment options.
Product Name:
SIGLEC3/CD33 Rabbit Polyclonal Antibody
SKU:
CAB2059
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 49-259 of human SIGLEC3/CD33 (NP_001763.3).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
40kDa
Observed MW:
70kDa
Enables protein phosphatase binding activity and sialic acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine phosphatase activity. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome.
Purification Method:
Affinity purification
Gene ID:
945
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using SIGLEC3/CD33 Rabbit pAb (CAB2059) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
