The CD31 (PECAM1) Rabbit Monoclonal Antibody (CAB19014) is a cutting-edge research tool designed for investigating CD31, also known as Platelet Endothelial Cell Adhesion Molecule-1, a cell surface protein involved in endothelial cell adhesion and signaling. The antibody, developed using rabbit monoclonal technology, exhibits high specificity and sensitivity for human samples and is optimized for various applications including immunofluorescence, immunohistochemistry, and flow cytometry.CD31 is a key player in vascular biology, regulating processes such as leukocyte migration, angiogenesis, and platelet activation. Its role in mediating cell-cell adhesion and transendothelial migration makes it a crucial target for research in cardiovascular diseases, inflammation, and cancer metastasis.
By utilizing the CD31 Rabbit Monoclonal Antibody, researchers can gain valuable insights into the function and localization of CD31 in different cell types and tissues, enabling a deeper understanding of its physiological and pathological roles.Overall, the CD31 Rabbit Monoclonal Antibody (CAB19014) is a reliable tool for studying the intricate mechanisms governed by CD31 in various biological processes, offering researchers the opportunity to unravel novel pathways and potential therapeutic targets in vascular and immune-related diseases.
Product Name:
CD31/PECAM1 Rabbit Monoclonal Antibody
SKU:
CAB19014
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 630-738 of CD31/PECAM1 (NP_000433.4).
Cell junction, Cell junction, Cell membrane, Lipid-anchor, Single-pass type I membrane protein.
Calculated MW:
83kDa
Observed MW:
135kDa
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.
Purification Method:
Affinity purification
Gene ID:
5175
Clone Number:
ARC50362
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CD31/PECAM1 (CAB19014) at 1:12500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
