The CD3 Epsilon Rabbit Monoclonal Antibody (CAB19017) is a specialized research tool for studying the CD3 Epsilon protein, an essential component of the T cell receptor complex involved in immune response signaling. This monoclonal antibody, developed in rabbits, is highly specific for human samples and has been rigorously validated for use in various applications, including Western blotting.By binding specifically to the CD3 Epsilon protein, this antibody enables accurate detection and analysis in a wide range of cell types, making it a valuable tool for researchers in the fields of immunology and cancer biology. Understanding the role of CD3 Epsilon in T cell activation and function is crucial for deciphering the mechanisms underlying immune responses and developing targeted therapies for diseases such as cancer and autoimmune disorders.
The CD3 Epsilon Rabbit Monoclonal Antibody (CAB19017) offers researchers a reliable and sensitive means of investigating the functions of CD3 Epsilon in various biological contexts, providing valuable insights into T cell signaling pathways and immune system regulation. With its high specificity and versatility, this antibody is a valuable asset for studies aimed at understanding the complex interplay between the immune system and disease processes.
Product Name:
CD3E Rabbit Monoclonal Antibody
SKU:
CAB19017
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CD3E (NP_000724.1).
Cell membrane, Single-pass type I membrane protein
Calculated MW:
23kDa
Observed MW:
23kDa
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
Purification Method:
Affinity purification
Gene ID:
916
Clone Number:
ARC51750
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CD3E Rabbit pAb (CAB19017) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
