CD2AP Rabbit Polyclonal Antibody (CAB7788)
- SKU:
- CAB7788
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | CD2AP Rabbit Polyclonal Antibody |
SKU: | CAB7788 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 360-639 of human CD2AP (NP_036252.1). |
Sequence: | KYFS LKPE EKDE KSTL EQKP SKPA APQV PPKK PTPP TKAS NLLR SSGT VYPK RPEK PVPP PPPI AKIN GEVS SISS KFET EPVS KLKL DSEQ LPLR PKSV DFDS LTVR TSKE TDVV NFDD IASS ENLL HLTA NRPK MPGR RLPG RFNG GHSP THSP EKIL KLPK EEDS ANLK PSEL KKDT CYSP KPSV YLST PSSA SKAN TTAF LTPL EIKA KVET DDVK KNSL DELR AQII ELLC IVEA LKKD HGKE LEKL RKDL EEEK TMRS NLEM EIEK LKKA VLSS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CMS; CD2AP |
Positive Sample: | A-431,Raji,MCF7,SW480,HL-60,Mouse kidney,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cell projection, Cytoplasm, cytoskeleton, ruffle. |
Calculated MW: | 71kDa |
Observed MW: | 90kDa |
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
Purification Method: | Affinity purification |
Gene ID: | 23607 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |