The CD276 Polyclonal Antibody is a valuable tool for researchers studying CD276, a co-stimulatory molecule that plays a key role in immune response regulation. This antibody, produced from rabbit serum, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the CD276 protein, researchers can accurately detect and analyze its expression in various cell types, making it ideal for investigations in immunology and cancer research.CD276, also known as B7-H3, is involved in immune regulation and has been linked to the development and progression of various cancers. Its ability to modulate immune responses makes it a promising target for the development of new therapeutic strategies in cancer treatment.
Research on CD276 is essential for gaining insights into its role in disease pathogenesis and for identifying potential therapeutic interventions that target this molecule.Overall, the CD276 Polyclonal Antibody is a valuable research tool that can help scientists better understand the functions of CD276 and its potential implications in cancer and immunology research. By using this antibody, researchers can further explore the role of CD276 in immune regulation and potentially uncover novel therapeutic approaches for managing cancer and other immune-related disorders.
Product Name:
CD276 Polyclonal Antibody
SKU:
CAB24668
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant Protein corresponding to a sequence within amino acids 29-245 of human CD276(NP_079516.1).
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
80381
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CD276 Rabbit pAb (CAB24668) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Negative control (NC):JurkatExposure time: 1s.
