CD276 Polyclonal Antibody (CAB24668)
- SKU:
- CAB24668
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Frequently bought together:
Description
Product Name: | CD276 Polyclonal Antibody |
SKU: | CAB24668 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant Protein corresponding to a sequence within amino acids 29-245 of human CD276(NP_079516.1). |
Sequence: | LEVQ VPED PVVA LVGT DATL CCSF SPEP GFSL AQLN LIWQ LTDT KQLV HSFA EGQD QGSA YANR TALF PDLL AQGN ASLR LQRV RVAD EGSF TCFV SIRD FGSA AVSL QVAA PYSK PSMT LEPN KDLR PGDT VTIT CSSY RGYP EAEV FWQD GQGV PLTG NVTT SQMA NEQG LFDV HSVL RVVL GANG TYSC LVRN PVLQ QDAH GSVT ITGQ PMTF P |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IHC-P,1:50 - 1:200 |
Synonyms: | B7H3; B7-H3; B7RP-2; 4Ig-B7-H3; CD276 |
Positive Sample: | U-2 OS,LNCaP |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 33kDa |
Observed MW: | 100kDa |
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 80381 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |