CD276/B7-H3 Polyclonal Antibody (CAB21663)
- SKU:
- CAB21663
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
CD276/B7-H3 Polyclonal Antibody (CAB21663)
The CD276 (B7-H3) Polyclonal Antibody (CAB21663) is a valuable tool for researchers studying CD276 (B7-H3), a member of the B7 family of immune checkpoint proteins involved in immune regulation and tumor immune evasion. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for Western blot applications to detect and analyze CD276 expression in various cell types.CD276 (B7-H3) is known for its role in immune response modulation and has been implicated in the progression of various cancers, making it a promising target for cancer immunotherapy research.
By targeting CD276, researchers may be able to develop novel therapies that enhance anti-tumor immune responses and inhibit tumor growth.With its ability to specifically bind to CD276 (B7-H3) protein, the CAB21663 polyclonal antibody provides a reliable tool for studying the function of CD276 in immunology and cancer research. By understanding the mechanisms underlying CD276-mediated immune regulation, researchers can advance their knowledge of tumor immune evasion and potentially uncover new therapeutic strategies for cancer treatment.
| Product Name: | CD276/B7-H3 Polyclonal Antibody |
| Product Code: | CAB21663 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 60-159 of human CD276/B7-H3 (NP_001019907.1). |
| Sequence: | LAQLN LIWQL TDTKQ LVHSF AEGQD QGSAY ANRTA LFPDL LAQGN ASLRL QRVRV ADEGS FTCFV SIRDF GSAAV SLQVA APYSK PSMTL EPNKD LRPGD |
| Synonyms: | B7H3, B7-H3, B7RP-2, 4Ig-B7-H3 |
| Calculated MW: | 57kDa |
| Observed MW: | Refer to figures |
Related Products
B7-H3/CD276 Rabbit Polyclonal Antibody (CAB17216)
Human CD276 / B7-H3 ELISA Kit
