The CD275 Polyclonal Antibody (CAB24440) is a vital tool for researchers studying CD275, a key immune checkpoint protein involved in immune regulation and T-cell activation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been extensively validated for use in Western blot applications. CD275, also known as inducible T-cell co-stimulator ligand (ICOSL), is essential for the activation and regulation of T-cells in the immune response. Its function in co-stimulating T-cell proliferation and cytokine production makes it a crucial target for studies in immunology, cancer research, and autoimmune diseases.
By specifically binding to the CD275 protein, this antibody enables precise detection and analysis in various cell types, providing valuable insights into immune response mechanisms and potentially leading to the development of novel immunotherapies. Researchers can rely on the CD275 Polyclonal Antibody to enhance their understanding of CD275's role in immune modulation and its implications for therapeutic interventions in conditions like cancer and autoimmune disorders.
Product Name:
CD275 Polyclonal Antibody
SKU:
CAB24440
Size:
100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 19-256 of human ICOSL (NP_056074.1).
Enables identical protein binding activity. Predicted to be involved in T cell receptor signaling pathway and positive regulation of interleukin-4 production. Located in cytoplasmic ribonucleoprotein granule and plasma membrane.
Purification Method:
Affinity purification
Gene ID:
23308
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse kidney, using CD275 Rabbit pAb (CAB24440) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
