CD274 Monoclonal Antibody (CAB23922)
- SKU:
- CAB23922
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | CD274 Monoclonal Antibody |
SKU: | CAB23922 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-235 of mouse CD274(NP_068693.1). |
Sequence: | FTIT APKD LYVV EYGS NVTM ECRF PVER ELDL LALV VYWE KEDE QVIQ FVAG EEDL KPQH SNFR GRAS LPKD QLLK GNAA LQIT DVKL QDAG VYCC IISY GGAD YKRI TLKV NAPY RKIN QRIS VDPA TSEH ELIC QAEG YPEA EVIW TNSD HQPV SGKR SVTT SRTE GMLL NVTS SLRV NATA NDVF YCTF WRSQ PGQN HTAE LIIP ELPA THPP Q |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1; CD274 |
Positive Sample: | Mouse thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Endomembrane system, Single-pass type I membrane protein. |
Calculated MW: | 33kDa |
Observed MW: | 40-50kDa |
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 60533 |
Clone Number: | ARC61782 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |