The CD27 Rabbit Monoclonal Antibody is a highly specific research tool designed for the detection and analysis of the CD27 protein in various cell types. CD27 is a cell surface molecule that plays a crucial role in immune regulation, particularly in activating immune responses. This antibody, generated in rabbits, is validated for use in Western blot applications and is highly reactive with human samples.CD27, also known as TNFRSF7, is a vital co-stimulatory molecule that promotes T-cell activation and proliferation. Its involvement in immune responses makes it a target of interest in immunology and cancer research.
By binding to the CD27 protein, this antibody enables researchers to study its function in different cellular contexts, providing insights into the mechanisms underlying immune activation and immune-mediated diseases.Understanding the role of CD27 in immune regulation is essential for developing targeted therapies for conditions such as cancer, autoimmune disorders, and infectious diseases. By using the CD27 Rabbit Monoclonal Antibody, researchers can unlock the potential of CD27 as a therapeutic target and further elucidate its implications in immune modulation.
Product Name:
CD27 Rabbit Monoclonal Antibody
SKU:
CAB11505
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CD27 (P26842).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Purification Method:
Affinity purification
Gene ID:
939
Clone Number:
ARC0625
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts from various cell lines, using CD27 Rabbit mAb (CAB11505) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
