The CD27 Polyclonal Antibody (CAB15654) is an essential tool for researchers studying CD27, a cell surface receptor involved in immune responses. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for Western blot applications. By binding to the CD27 protein, this antibody allows for the detection and analysis of CD27 in various cell types, making it a valuable asset for studies in immunology and cancer research.CD27, also known as a T-cell activation antigen, plays a key role in regulating immune responses and promoting T-cell activation and differentiation.
Its involvement in immune signaling pathways makes it a promising target for research into diseases such as cancer and autoimmune disorders. Understanding the function of CD27 is crucial for developing novel therapeutic strategies that can modulate immune responses in these pathological conditions. Overall, the CD27 Polyclonal Antibody is a reliable and versatile tool for researchers seeking to explore the role of CD27 in immune regulation and disease pathogenesis.
Product Name:
CD27 Rabbit Polyclonal Antibody
SKU:
CAB15654
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-191 of human CD27 (NP_001233.1).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Purification Method:
Affinity purification
Gene ID:
939
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse lung, using CD27 Rabbit pAb (CAB15654) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
