The CD27 Antigen Polyclonal Antibody (CAB1945) is a valuable tool for researchers studying CD27, a cell surface molecule involved in immune response regulation and lymphocyte activation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications. By binding specifically to the CD27 antigen, this antibody enables precise detection and analysis of CD27 expression in various cell types, making it an excellent choice for studies in immunology, oncology, and infectious diseases.CD27, also known as Tumor Necrosis Factor Receptor Superfamily Member 7 (TNFRSF7), plays a crucial role in immune cell activation, proliferation, and differentiation.
Its importance in immune response modulation highlights its relevance in various disease states, including cancer and autoimmune disorders. By investigating the function of CD27, researchers can gain insights into immune system dysregulation and potentially identify therapeutic targets for treating immune-related conditions.Overall, the CD27 Antigen Polyclonal Antibody serves as a valuable tool for researchers interested in understanding the role of CD27 in immune function and disease pathogenesis. Its high specificity and reactivity make it an essential component of any investigation involving CD27-mediated immune responses.
Product Name:
CD27 Rabbit Polyclonal Antibody
SKU:
CAB1945
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-191 of human CD27 (NP_001233.1).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Purification Method:
Affinity purification
Gene ID:
939
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Raji cells, using CD27 Rabbit pAb (CAB1945) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
