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CD25 monoclonal antibody (APC) (AGIM0467)

SKU:
AGIM0467
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
MEM-181
Conjugation:
APC
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD25 monoclonal antibody (APC)
Product Code:AGIM0467
Size:100 µL
Reactivity:Human
Clone:MEM-181
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P01589
Background:CD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit CD25 constitues the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. CD25 expression rapidly increases upon T cell activation. The 55 kDa CD25 molecule is enzymatically cleaved and shed from the cell surface as a soluble 45 kDa s-Tac, whose concentration in serum can be used as a marker of T cell activation. Expression of CD25 indicates the neoplastic phenotype of mast cells. Humanized anti CD25 antibodies represent a useful tool to reduce the incidence of allograft rejection as well as the severity of graft versus host reaction, and radioimmunoconjugates of anti-CD25 antibodies can be used against CD25 expressing lymphomas.
UniProt Protein Function:IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 10p15.1

Cellular Component: plasma membrane

Molecular Function:interleukin-2 binding; Ras guanyl-nucleotide exchange factor activity

Biological Process: apoptosis; cell proliferation; cell surface receptor linked signal transduction; immune response; inflammatory response; MAPKKK cascade; regulation of T cell tolerance induction

Disease: Diabetes Mellitus, Insulin-dependent, 10; Interleukin 2 Receptor, Alpha, Deficiency Of

NCBI Summary:The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
UniProt Code:P01589
NCBI GenInfo Identifier:124317
NCBI Gene ID:3559
NCBI Accession:P01589.1
UniProt Secondary Accession:P01589,Q5W007,
UniProt Related Accession:P01589
Molecular Weight:30,819 Da
NCBI Full Name:Interleukin-2 receptor subunit alpha
NCBI Synonym Full Names:interleukin 2 receptor subunit alpha
NCBI Official Symbol:IL2RA  
NCBI Official Synonym Symbols:p55; CD25; IL2R; IMD41; TCGFR; IDDM10  
NCBI Protein Information:interleukin-2 receptor subunit alpha
UniProt Protein Name:Interleukin-2 receptor subunit alpha
UniProt Synonym Protein Names:TAC antigen; p55; CD_antigen: CD25
UniProt Gene Name:IL2RA  

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