The CD247 Polyclonal Antibody (CAB2058) is a vital tool for researchers studying CD247, a cell surface receptor essential for T cell activation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CD247 protein, this antibody enables precise detection and analysis in various cell types, making it an invaluable resource for studies in immunology and cancer research.CD247, also known as the CD3 zeta chain, is a critical component of the T cell receptor complex and is essential for signal transduction during T cell activation.
Understanding the function and regulation of CD247 is crucial for unraveling the complexities of T cell-mediated immune responses, making this antibody a valuable tool for investigating diseases such as cancer and autoimmune disorders. By targeting CD247, researchers can gain insights that may lead to the development of novel therapies aimed at modulating T cell activity in various disease contexts.
Product Name:
CD3H Rabbit Polyclonal Antibody
SKU:
CAB2058
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-164 of human CD3H (NP_932170.1).
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
919
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD3H Rabbit pAb (CAB2058) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
