The CD22 Polyclonal Antibody (CAB5790) is a high-quality research tool specifically designed for studying CD22, a B-cell receptor that plays a key role in the regulation of B-cell activation and signaling. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot and immunohistochemistry applications.CD22 is a transmembrane protein found on B cells, where it functions as a negative regulator of B-cell receptor signaling, inhibiting excessive activation and promoting immune tolerance. Research into CD22 has shown its involvement in autoimmune diseases, B-cell lymphomas, and other immune-related disorders, making it a promising target for therapeutic interventions.
By utilizing the CD22 Polyclonal Antibody in your research, you can effectively detect and analyze the expression of CD22 in various cell types and tissues. This antibody's specificity and reliability make it an indispensable tool for investigations in immunology, oncology, and autoimmune disease research. Gain valuable insights into the role of CD22 in immune function and disease pathology with the use of this high-quality antibody from Assay Genie.
Product Name:
CD22 Rabbit Polyclonal Antibody
SKU:
CAB5790
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 708-847 of human CD22 (NP_001762.2).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
95kDa
Observed MW:
140kDa
Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in B cell activation; negative regulation of B cell receptor signaling pathway; and regulation of endocytosis. Located in early endosome and recycling endosome.
Purification Method:
Affinity purification
Gene ID:
933
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Raji cells, using CD22 antibody (CAB5790) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
