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APC Anti-Human CD22 Antibody [BU59]

SKU:
AGEL2819
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG1, κ
Clone:
BU59
Conjugation:
APC
€169 - €579
Frequently bought together:

Description

APC Anti-Human CD22 Antibody [BU59]

The Anti-Human CD22 Antibody (BU59) is a valuable tool for researchers studying CD22, a surface protein primarily found on B cells and involved in B cell activation and regulation. This monoclonal antibody, pictured to the right in Figure 1, is specifically designed to target the CD22 protein in human samples and is validated for use in various immunoassays like flow cytometry and immunohistochemistry.CD22 is known for its role in regulating B cell signaling and activation, making it a key player in the adaptive immune response. Its expression pattern and function have been linked to various immune-related disorders, including autoimmune diseases and certain B cell lymphomas. Understanding the behavior of CD22 at the molecular level is essential for unraveling its impact on immune function and its potential as a therapeutic target.

The Anti-Human CD22 Antibody (BU59) offers high specificity and sensitivity in detecting CD22 expression, making it an excellent tool for investigating the roles of CD22 in health and disease. Whether studying B cell biology, immunology, or exploring potential treatment avenues, this antibody provides researchers with a reliable means to delve deeper into the complexities of CD22 and its implications in immune-related contexts.To learn more about the Anti-Human CD22 Antibody (BU59) and how it can advance your research, please visit the provided URL for detailed product information and specifications.

Product Name:APC Anti-Human CD22 Antibody [BU59]
Product Code:AGEL2819
Clone No:BU59
Synonyms:B-cell receptor CD22,Cd22,B-lymphocyte cell adhesion molecule,BL-CAM,Sialic acid-binding Ig-like lectin 2,Siglec-2,T-cell surface antigen Leu-14,CD22,Lyb-8, Siglec2
Reactivity:Human
Host Species:Mouse
Applications:FCM
Isotype:Mouse IgG1, κ
Isotype Control:APC Mouse IgG1, κ Isotype Control [MOPC-21] (AGEL2551)
Conjugation:APC
Form:Liquid
Fluorescent Label:APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter).
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Swissprot:P20273
Stability & Storage:Keep as concentrated solution. Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Shipping:Biological ice pack at 4°C

CD22 is a 130 kD type I transmembrane glycoprotein also known as Siglec-2 and BL-CAM. It is a member of the immunoglobulin superfamily (sialoadhesion subgroup). CD22 is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature B and activated B cells, but not on plasma cells. CD22 is present in the B cell receptor complex and associates with SHP-1, Syk, Lck, Lyn, and phospholipase Cγ1. A primary function of CD22 is thought to be in limiting antigen receptor signaling by modulating B cell activation threshold. CD22 has been shown to bind to CD45RO and CD75, although the natural ligands for this molecule remain controversial.

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