The CD209 Rabbit Monoclonal Antibody (CAB9649) is a potent tool for research involving CD209, a cell surface receptor known for its role in immune responses and pathogen recognition. This antibody, developed using rabbit monoclonal technology, exhibits high specificity and sensitivity in detecting CD209 in human samples. Validated for use in various applications such as Western blotting, the antibody binds specifically to the CD209 protein, enabling accurate and reliable detection in a wide range of cell types.CD209, also known as DC-SIGN, is a key player in the immune system, particularly in the recognition and uptake of pathogens by dendritic cells. Its ability to interact with a variety of pathogens, including viruses, bacteria, and parasites, makes it a valuable target for research in infectious diseases and vaccine development.
By understanding the function and regulation of CD209, researchers can gain insights into immune responses and potentially develop novel strategies for combating infections and enhancing vaccine efficacy.Overall, the CD209 Rabbit Monoclonal Antibody (CAB9649) provides researchers with a powerful tool for investigating the role of CD209 in immunity, infection, and vaccine development. Its high specificity and sensitivity make it an essential component for studies in immunology, microbiology, and infectious disease research.
Product Name:
CD209 Rabbit Monoclonal Antibody
SKU:
CAB9649
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CD209 (Q9NNX6).
Cell membrane, Single-pass type II membrane protein, Secreted.
Calculated MW:
46kDa
Observed MW:
45-55kDa
This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity.
Purification Method:
Affinity purification
Gene ID:
30835
Clone Number:
ARC1679
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD209 Rabbit mAb (CAB9649) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
