The CD209 Antigen Polyclonal Antibody (CAB1466) is a powerful tool for researchers studying the CD209 antigen, a key player in immune regulation and host-pathogen interactions. This polyclonal antibody, produced using rabbit immunization, is highly specific to human samples and has been rigorously validated for use in Western blot applications. By binding to the CD209 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it perfect for studies in immunology and infectious disease research.CD209, also known as DC-SIGN, is a C-type lectin receptor expressed on dendritic cells and macrophages, where it plays a critical role in pathogen recognition and immune response modulation.
Its ability to interact with a wide range of pathogens, including viruses, bacteria, and fungi, makes it an attractive target for investigating host-pathogen interactions and developing novel therapeutics. By understanding the function of CD209, researchers can gain insight into immune responses to infectious agents and potentially uncover new strategies for combating infectious diseases.Overall, the CD209 Antigen Polyclonal Antibody (CAB1466) is essential for researchers looking to unravel the complexities of immune regulation and host defense mechanisms, making it a valuable tool for advancing our understanding of infectious diseases and immune-related disorders.
Product Name:
CD209 Rabbit Polyclonal Antibody
SKU:
CAB1466
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 265-404 of human CD209 (NP_066978.1).
Cell membrane, Secreted, Single-pass type II membrane protein.
Calculated MW:
46kDa
Observed MW:
55kDa
This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity.
Purification Method:
Affinity purification
Gene ID:
30835
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of THP-1 cells, using CD209 antibody (CAB1466) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
