The CD200 Polyclonal Antibody (CAB6552) is a valuable tool for research involving CD200, a cell surface glycoprotein with immunomodulatory properties. This antibody is produced in rabbits and exhibits high specificity for human samples, making it ideal for use in experiments such as Western blotting.CD200 is known to play a crucial role in immune regulation by suppressing inflammatory responses and promoting immune tolerance. Its involvement in immune function suggests its potential as a therapeutic target for diseases characterized by dysregulated immune responses, such as cancer and autoimmune disorders.
By utilizing the CD200 Polyclonal Antibody, researchers can effectively detect and analyze the CD200 protein in various cell types, facilitating studies in immunology, oncology, and other areas of biomedical research. Understanding the mechanisms underlying CD200's immunomodulatory effects is essential for the development of novel treatment strategies aimed at modulating immune responses in disease settings.
Product Name:
CD200 Rabbit Polyclonal Antibody
SKU:
CAB6552
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-240 of human CD200 (NP_005935.4).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
31kDa
Observed MW:
45-50kDa
This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
4345
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CD200 antibody (CAB6552) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
