Anti-CD2 Antibody (PE) (AGIM0142)

CD2 monoclonal antibody (PE) (AGIM0142)

SKU:

AGIM0142

Product Type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Host Species:

Mouse

Isotype:

IgG2a

Clone:

LT2

Conjugation:

Applications:

Description

Description

Datasheet

Isotype:	IgG2a
Host Species:	Mouse
Storage:	Store at 4°C. Avoid prolonged exposure to light.
Uniprot:	P06729
Background:	CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.

UniProt Protein Function:	CD2: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.
UniProt Protein Details:	Protein type:Cell surface; Membrane protein, integral; Apoptosis Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: anchored to plasma membrane; cell surface; external side of plasma membrane; extracellular region; integral to plasma membrane; intercellular junction; internal side of plasma membrane; plasma membrane Molecular Function:protein binding; protein homodimerization activity; receptor activity; receptor binding Biological Process: apoptosis; cell surface receptor linked signal transduction; cell-cell adhesion; heterotypic cell-cell adhesion; leukocyte migration; lipid raft polarization; natural killer cell activation; positive regulation of myeloid dendritic cell activation; positive regulation of tumor necrosis factor production; regulation of T cell differentiation; T cell activation
NCBI Summary:	CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]
UniProt Code:	P06729
NCBI GenInfo Identifier:	160370002
NCBI Gene ID:	914
NCBI Accession:	P06729.2
UniProt Secondary Accession:	P06729,Q96TE5,
UniProt Related Accession:	P06729
Molecular Weight:	39,448 Da
NCBI Full Name:	T-cell surface antigen CD2
NCBI Synonym Full Names:	CD2 molecule
NCBI Official Symbol:	CD2
NCBI Official Synonym Symbols:	T11; SRBC; LFA-2
NCBI Protein Information:	T-cell surface antigen CD2
UniProt Protein Name:	T-cell surface antigen CD2
UniProt Synonym Protein Names:	Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD_antigen: CD2
Protein Family:	CD2
UniProt Gene Name:	CD2
UniProt Entry Name:	CD2_HUMAN