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CD2 monoclonal antibody (PE) (AGIM0025)

SKU:
AGIM0025
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
MEM-65
Conjugation:
PE
Applications:
FC
€179
Frequently bought together:

Description

system_update_altDatasheet
Product Name:CD2 monoclonal antibody (PE)
Product Code:AGIM0025
Size:500 µL
Reactivity:Human
Clone:MEM-65
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Do not freeze. Avoid prolonged exposure to light.
Uniprot:P06729 
Background:CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Morover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cellcell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.

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