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CD2 monoclonal antibody (APC ) (AGIM0453)

SKU:
AGIM0453
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
HIT11
Conjugation:
APC
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD2 monoclonal antibody (APC )
Product Code:AGIM0453
Size:100 µL
Reactivity:Human
Clone:HIT11
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P06729
Background:CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.
UniProt Protein Function:CD2: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: anchored to plasma membrane; cell surface; external side of plasma membrane; extracellular region; integral to plasma membrane; intercellular junction; internal side of plasma membrane; plasma membrane

Molecular Function:protein binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: apoptosis; cell surface receptor linked signal transduction; cell-cell adhesion; heterotypic cell-cell adhesion; leukocyte migration; lipid raft polarization; natural killer cell activation; positive regulation of myeloid dendritic cell activation; positive regulation of tumor necrosis factor production; regulation of T cell differentiation; T cell activation

NCBI Summary:CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]
UniProt Code:P06729
NCBI GenInfo Identifier:160370002
NCBI Gene ID:914
NCBI Accession:P06729.2
UniProt Secondary Accession:P06729,Q96TE5,
UniProt Related Accession:P06729
Molecular Weight:39,448 Da
NCBI Full Name:T-cell surface antigen CD2
NCBI Synonym Full Names:CD2 molecule
NCBI Official Symbol:CD2  
NCBI Official Synonym Symbols:T11; SRBC; LFA-2  
NCBI Protein Information:T-cell surface antigen CD2
UniProt Protein Name:T-cell surface antigen CD2
UniProt Synonym Protein Names:Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD_antigen: CD2
Protein Family:CD2
UniProt Gene Name:CD2  
UniProt Entry Name:CD2_HUMAN

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