The CD1e Monoclonal Antibody (PACO56744) is a valuable research tool designed for the study of CD1e, a cell surface protein involved in antigen presentation to T lymphocytes. This antibody, produced using monoclonal technology, specifically recognizes human CD1e and has been validated for use in various applications including immunohistochemistry and flow cytometry.CD1e is a member of the CD1 family of proteins that play a crucial role in the immune response by presenting lipid antigens to T cells. Understanding the function of CD1e is essential for research in immunology, infectious diseases, and autoimmunity.
This antibody enables researchers to detect and analyze CD1e expression in different cell types, providing valuable insights into its role in immune regulation and disease pathology.With its high specificity and sensitivity, the CD1e Monoclonal Antibody (PACO56744) is a reliable tool for investigating the biological functions of CD1e in health and disease. Its use in research may contribute to the development of novel therapeutic strategies targeting CD1e-mediated immune responses in various clinical contexts.
Antibody Name:
CD1E Antibody (PACO56744)
Antibody SKU:
PACO56744
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human T-cell surface glycoprotein CD1e, membrane-associated protein (198-294AA)
IHC image of PACO56744 diluted at 1:300 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.
T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010]
