The CD1e Polyclonal Antibody (PACO00552) is a vital tool for researchers studying the CD1e molecule, which plays a key role in antigen presentation to T cells. This antibody, generated in rabbits, shows high reactivity with human samples and is validated for use in a variety of applications including Western blot and immunohistochemistry. By binding specifically to the CD1e protein, this antibody enables accurate detection and analysis in different cell types, making it ideal for investigations in immunology and infectious diseases.
CD1e is a member of the CD1 family of proteins that present lipid antigens to T cells, initiating immune responses against pathogens. Its unique function in lipid antigen presentation makes it a promising target for research into host-pathogen interactions, vaccine development, and immunotherapy. Understanding the role of CD1e in immune responses is crucial for designing therapeutic strategies to combat infectious diseases and enhance immune defenses.
Antibody Name:
CD1E Antibody
Antibody SKU:
PACO00552
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human CD1e.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010]
