The CD1a Monoclonal Antibody (PACO08271) is an essential tool for researchers studying CD1a, a cell surface protein involved in antigen presentation and T cell activation. This antibody, produced through hybridoma technology, exhibits high specificity and sensitivity for detecting CD1a in human samples. Validated for use in immunohistochemistry applications, it allows for precise visualization and localization of CD1a in tissue samples.CD1a, a member of the CD1 family of glycoproteins, is primarily expressed on dendritic cells and thymocytes.
It plays a crucial role in presenting lipid antigens to T cells, initiating immune responses against foreign pathogens. Research on CD1a is vital for understanding immune surveillance, anti-tumor immunity, and autoimmune responses. The CD1a Monoclonal Antibody opens doors for investigating the function and regulation of CD1a in various immunological contexts, providing valuable insights for the development of novel immunotherapies and vaccines.
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
NCBI Summary:
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
