The CD177 Antigen Polyclonal Antibody (CAB6550) is a valuable tool for researchers studying the CD177 antigen, a glycoprotein expressed on the surface of neutrophils. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for Western blot applications.CD177 is involved in the regulation of neutrophil activation and migration, making it a key player in inflammatory responses and immune defense mechanisms. Studies have shown its potential role in various diseases, including inflammatory disorders and cancer, making it a promising target for further investigation.
By using the CD177 Antigen Polyclonal Antibody, researchers can effectively detect and analyze CD177 expression in different cell types, providing insights into its function in immune responses and disease development. This antibody is an essential tool for studies in immunology, inflammation, and cancer research, offering valuable information for the development of potential therapies targeting CD177-related pathways.
Product Name:
CD177 Rabbit Polyclonal Antibody
SKU:
CAB6550
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 35-285 of human CD177 (NP_065139.2).
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified.
Purification Method:
Affinity purification
Gene ID:
57126
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Mouse bone marrow, using CD177 antibody (CAB6550) at 1:800 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
