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CD17 monoclonal antibody (FITC) (AGIM0311)

SKU:
AGIM0311
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgM
Clone:
HIP10
Conjugation:
FITC
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD17 monoclonal antibody (FITC)
Product Code:AGIM0311
Size:100 µL
Reactivity:Human
Clone:HIP10
Applications:Flow Cytometry
Conjugate:FITC
Isotype:IgM
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:F4KHL6
Background:CD17, lactosylceramide, is an ubiquitous glycosphingolipid with uncharged disaccharide headgroup, highly enriched in lipid raft-derived structures. Besides playing a pivotal role in the biosynthesis of complex glycosphingilipids, lactosylceramide is involved in cell-cell and cell-matrix interactions and in signaling events linked to cell differentiation, development, apoptosis and oncogenesis. Lactosylceramide regulates integrin functions and production of nitric oxide. Its expression defines successive stages in the maturation of myeloid cells. Lactosylceramide (LaCer) is present on peripheral blood granulocytes including basophils, monocytes, platelets and a subset of B cells (40-80% CD19+). In tissues, CDw17 is found on tonsillar dendritic cells, epithelial cells, intestinal epithelium and endothelial. CDw17 antigen may play a role in phagocytosis.

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