CD163 Rabbit Polyclonal Antibody (CAB8383)
- SKU:
- CAB8383
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | CD163 Rabbit Polyclonal Antibody |
SKU: | CAB8383 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 750-1050 of human CD163 (NP_004235.4?). |
Sequence: | LSDA HVVC RQLG CGEA INAT GSAH FGEG TGPI WLDE MKCN GKES RIWQ CHSH GWGQ QNCR HKED AGVI CSEF MSLR LTSE ASRE ACAG RLEV FYNG AWGT VGKS SMSE TTVG VVCR QLGC ADKG KINP ASLD KAMS IPMW VDNV QCPK GPDT LWQC PSSP WEKR LASP SEET WITC DNKI RLQE GPTS CSGR VEIW HGGS WGTV CDDS WDLD DAQV VCQQ LGCG PALK AFKE AEFG QGTG PIWL NEVK CKGN ESSL WDCP ARRW GHSE CGHK EDAA VNCT DISV QKTP QKAT TGRS SRQS S |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | M130; MM130; SCARI1; CD163 |
Positive Sample: | 293T-CD163 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 125kDa |
Observed MW: | 160kDa |
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 9332 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |