The CD163 Polyclonal Antibody (CAB8383) offered by AssayGenie is a valuable tool for researchers studying CD163, a cell surface protein involved in immune regulation and inflammation. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the CD163 protein, this antibody enables the detection and analysis of CD163 in various cell types, making it an essential tool for studies in immunology and cancer research.CD163, also known as a scavenger receptor, plays a crucial role in regulating the immune response and inflammatory processes. Its involvement in these pathways makes it a promising target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
Understanding the function of CD163 is essential for the development of potential therapies aimed at modulating immune responses in these disease contexts.Overall, the CD163 Polyclonal Antibody from AssayGenie is a reliable reagent for researchers looking to investigate the role of CD163 in immune regulation and inflammation. Its high specificity and validation for Western blot applications make it a valuable tool for advancing our understanding of this important cell surface molecule.
Product Name:
CD163 Rabbit Polyclonal Antibody
SKU:
CAB8383
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 750-1050 of human CD163 (NP_004235.4?).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
125kDa
Observed MW:
160kDa
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
9332
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T-CD163 cells, using CD163 Rabbit pAb (CAB8383) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
