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Cd163 Antibody (PACO35870)

SKU:
PACO35870
Product Type:
Antibody
Reactivity:
Mouse
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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Cd163 Antibody (PACO35870)

The CD163 Polyclonal Antibody (PAC035870) is a powerful tool for researchers studying CD163, a cell surface molecule with important roles in immune regulation and inflammation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the CD163 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for investigations in the fields of immunology and cancer research.CD163, also known as a scavenger receptor, plays a pivotal role in immune response modulation by promoting anti-inflammatory processes and regulating macrophage activation.

Its involvement in various disease states, including cancer and inflammatory disorders, highlights its potential as a therapeutic target for novel treatment strategies. Comprehensive understanding of CD163 function is essential for developing effective interventions that modulate immune responses in disease contexts.A versatile tool for researchers, the CD163 Polyclonal Antibody (PAC035870) offers valuable insights into the regulatory mechanisms of CD163, paving the way for breakthrough discoveries in immunology and beyond.

Antibody Name:Cd163 Antibody (PACO35870)
Antibody SKU:PACO35870
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:2000
Species Reactivity:Mouse, Human
Immunogen:Recombinant Mouse Scavenger receptor cysteine-rich type 1 protein M130 protein (86-365AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot. Positive WB detected in: HL60 whole cell lysate. All lanes: Cd163 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 121, 126 kDa. Observed band size: 121 kDa.
Background:Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity).
Synonyms:Scavenger receptor cysteine-rich type 1 protein M130 (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)], Cd163, M130
UniProt Protein Function:CD163: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Cellular Component: membrane; extracellular region; plasma membrane; integral to membrane

Molecular Function:scavenger receptor activity

Biological Process: receptor-mediated endocytosis; acute-phase response; inflammatory response

UniProt Code:Q2VLH6
NCBI GenInfo Identifier:341940294
NCBI Gene ID:93671
NCBI Accession:Q2VLH6.2
UniProt Secondary Accession:Q2VLH6,Q2VLH5, Q99MX8, A6H691,
UniProt Related Accession:Q2VLH6
Molecular Weight:125,292 Da
NCBI Full Name:Scavenger receptor cysteine-rich type 1 protein M130
NCBI Synonym Full Names:CD163 antigen
NCBI Official Symbol:Cd163  
NCBI Official Synonym Symbols:CD163v2; CD163v3  
NCBI Protein Information:scavenger receptor cysteine-rich type 1 protein M130
UniProt Protein Name:Scavenger receptor cysteine-rich type 1 protein M130
UniProt Synonym Protein Names:CD_antigen: CD163Cleaved into the following chain:Soluble CD163; sCD163
Protein Family:Scavenger receptor cysteine-rich type 1 protein
UniProt Gene Name:Cd163  
UniProt Entry Name:C163A_MOUSE
ELISA Kits
Mouse Scavenger receptor cysteine-rich type 1 protein M130 (Cd163) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
Recommended Products
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

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