CD160 Rabbit Polyclonal Antibody (CAB8189)
- SKU:
- CAB8189
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
Product Name: | CD160 Rabbit Polyclonal Antibody |
SKU: | CAB8189 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human CD160 (NP_008984.1). |
Sequence: | MLLE PGRG CCAL AILL AIVD IQSG GCIN ITSS ASQE GTRL NLIC TVWH KKEE AEGF VVFL CKDR SGDC SPET SLKQ LRLK RDPG IDGV GEIS SQLM FTIS QVTP LHSG TYQC CARS QKSG IRLQ GHFF SILF TETG NYTV TGLK QRQH LEFS HNEG TLSS GFLQ EKVW VMLV TSLV ALQA L |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | NK1; BY55; NK28; CD160 |
Positive Sample: | Jurkat,HT-29,U-937,Raji,Mouse spleen,Mouse small intestine,Mouse thymus,Rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, GPI-anchor, Lipid-anchor. |
Calculated MW: | 20kDa |
Observed MW: | 20kDa |
CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.
Purification Method: | Affinity purification |
Gene ID: | 11126 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |