The CD155/PVR Rabbit Monoclonal Antibody (CAB5138) is a powerful tool for research involving CD155, also known as poliovirus receptor (PVR). This cell surface protein is involved in various biological processes, including cell adhesion and immune response regulation. The antibody, produced in rabbits, is highly specific and sensitive for detecting CD155/PVR in human samples. Validated for use in Western blot applications, this antibody enables precise detection and analysis of CD155/PVR expression in a variety of cell types.CD155/PVR has been implicated in immune modulation and its dysregulation has been associated with diseases such as cancer, viral infections, and autoimmune disorders.
By targeting CD155/PVR, researchers can gain insights into its role in disease pathology and potentially identify novel therapeutic strategies.Overall, the CD155/PVR Rabbit Monoclonal Antibody (CAB5138) is a valuable tool for studies in immunology, oncology, and infectious diseases, providing researchers with the means to investigate the functions of CD155/PVR and its implications for human health.
Product Name:
CD155/PVR Rabbit Monoclonal Antibody
SKU:
CAB5138
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CD155/PVR (P15151).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
45kDa
Observed MW:
70kDa
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5817
Clone Number:
ARC1178
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CD155/PVR Rabbit mAb (CAB5138) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
