The CD152 (CTLA-4) Monoclonal Antibody is a cutting-edge tool for research on the CD152 (CTLA-4) protein, a critical regulator of immune responses. This antibody, produced with high specificity and affinity, is ideal for use in various research applications, particularly in the fields of immunology and cancer research.The CD152 (CTLA-4) protein, also known as cytotoxic T-lymphocyte-associated protein 4, functions as a key checkpoint molecule in immune system modulation, specifically inhibiting T cell activation and promoting immune tolerance. Its role in immune regulation makes it a promising target for therapeutic interventions in conditions such as cancer, autoimmune diseases, and inflammatory disorders.
With this monoclonal antibody, researchers can effectively detect and analyze the expression of CD152 (CTLA-4) in various cell types, enabling a deeper understanding of its function and potential implications in disease pathology. By using this antibody in experiments such as Western blotting and immunohistochemistry, researchers can uncover novel insights into the mechanisms underlying immune responses and develop innovative strategies for therapeutic intervention.
Product Name:
CD152/CTLA-4 Monoclonal Antibody
SKU:
CAB22865
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 37-162 of human CD152/CTLA-4 (NP_005205.2).
293F transfected with CD152/CTLA-4,Recombinant Human CTLA-4 Protein
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane.
Calculated MW:
25kDa
Observed MW:
25kDa
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Purification Method:
Affinity purification
Gene ID:
1493
Clone Number:
ARC57390
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293F cells transfected with CD152/CTLA-4 using CD152/CTLA-4 Rabbit mAb (CAB22865) at 1:8000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
