CD152/CTLA-4 Monoclonal Antibody (CAB22865)
- SKU:
- CAB22865
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Frequently bought together:
Description
Product Name: | CD152/CTLA-4 Monoclonal Antibody |
SKU: | CAB22865 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-162 of human CD152/CTLA-4 (NP_005205.2). |
Sequence: | AMHV AQPA VVLA SSRG IASF VCEY ASPG KATE VRVT VLRQ ADSQ VTEV CAAT YMMG NELT FLDD SICT GTSS GNQV NLTI QGLR AMDT GLYI CKVE LMYP PPYY LGIG NGTQ IYVI DPEP CPDS DF |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:2000 - 1:9000 |
Synonyms: | CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3; CD152/CTLA-4 |
Positive Sample: | 293F transfected with CD152/CTLA-4,Recombinant Human CTLA-4 Protein |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane. |
Calculated MW: | 25kDa |
Observed MW: | 25kDa |
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Purification Method: | Affinity purification |
Gene ID: | 1493 |
Clone Number: | ARC57390 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |