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CD15 monoclonal antibody (PE) (AGIM0348)

SKU:
AGIM0348
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgM
Clone:
HI98
Conjugation:
PE
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD15 monoclonal antibody (PE)
Product Code:AGIM0348
Size:100 µL
Reactivity:Human
Clone:HI98
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgM
Host Species:Mouse
Storage:Store at 4°C. Do not freeze. Avoid prolonged exposure to light.
Uniprot:P22083
Background:CD15 (Lewis X, Le(x); stage specific embryonic antigen-1, SSEA-1) is a trisacharide determinant (3-fucosyl-N-acetyllactosamine) expressed on several glycolipids, glycoproteins and proteoglycans of various cell types, e.g. granulocytes, mast cells, monocytes, macrophages, cells of gastric mucosa, nervous system or various tumour cells. There are several variants of Lewis x, such as sialyl-Lewis x or sulphated Lewis x. Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation, based on calcium-dependent Le(x)-Le(x) interaction. This process is involved for example in embryo compaction or in autoaggregation of teratocarcinoma cells. Sialyl-Le(x) and its isomer sialyl-Le(a) are ligands of selectins. CD15 expression has been extensively used to confirm diagnosis of Hodgkin??s disease.
UniProt Protein Function:FUT4: May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens. Belongs to the glycosyltransferase 10 family.
UniProt Protein Details:

Protein type:Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; EC 2.4.1.-; Transferase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q21

Cellular Component: Golgi apparatus; membrane

Molecular Function:alpha(1,3)-fucosyltransferase activity; fucosyltransferase activity

Biological Process: carbohydrate metabolic process; protein amino acid glycosylation

NCBI Summary:The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]
UniProt Code:P22083
NCBI GenInfo Identifier:226694189
NCBI Gene ID:2526
NCBI Accession:P22083.3
UniProt Secondary Accession:P22083,B2RMS0,
UniProt Related Accession:P22083
Molecular Weight:59,084 Da
NCBI Full Name:Alpha-(1,3)-fucosyltransferase 4
NCBI Synonym Full Names:fucosyltransferase 4
NCBI Official Symbol:FUT4  
NCBI Official Synonym Symbols:LeX; CD15; ELFT; FCT3A; FUTIV; SSEA-1; FUC-TIV  
NCBI Protein Information:alpha-(1,3)-fucosyltransferase 4
UniProt Protein Name:Alpha-(1,3)-fucosyltransferase 4
UniProt Synonym Protein Names:ELAM-1 ligand fucosyltransferase; Fucosyltransferase 4; Fucosyltransferase IV; Fuc-TIV; FucT-IV; Galactoside 3-L-fucosyltransferase
Protein Family:Probable fucosyltransferase
UniProt Gene Name:FUT4  
UniProt Entry Name:FUT4_HUMAN

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