Anti-CD147 Antibody (AGIM0085)

CD147 monoclonal antibody (AGIM0085)

SKU:

AGIM0085

Product Type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Host Species:

Mouse

Isotype:

IgG1

Clone:

MEM-M6/1

Conjugation:

Unconjugated

Applications:

Description

Description

Datasheet

Isotype:	IgG1
Host Species:	Mouse
Storage:	Storage conditions:Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Uniprot:	P35613
Background:	CD147 (basigin, neurothelin, OX-47, 5A11, CE9, M6) also known as EMMPRIN (extracellular matrix metalloproteinase inducer) or TCSF (tumour cell-derived collagenase-stimulatory factor) is an ubiquitously expressed cell surface protein with multiple glycosylated forms. The highest level of CD147 expression is on metabolically active cells, such as lymphoblasts, inflammatory cells, brown adipocytes and malignant tumour cells. CD147 has multiple functions, including facilitating of cell surface expression of monocarboxylate transporter proteins and extracellular matrix metalloproteinases, regulation of integrin functions, it plays roles in cell development and activation, fetal development or retinal function.

UniProt Protein Function:	BSG: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor. Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM. Interacts with AJAP1. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral; Immunoglobulin superfamily Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: acrosomal membrane; focal adhesion; Golgi membrane; integral to plasma membrane; lipid raft; melanosome; membrane; mitochondrion; plasma membrane; sarcolemma Molecular Function:mannose binding; protein binding Biological Process: blood coagulation; cell surface receptor linked signal transduction; cellular metabolic process; decidualization; embryo implantation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; leukocyte migration; odontogenesis of dentine-containing teeth; pyruvate metabolic process; response to cAMP; response to mercury ion; response to peptide hormone stimulus Disease: Blood Group--ok
NCBI Summary:	The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	P35613
NCBI GenInfo Identifier:	51704273
NCBI Gene ID:	682
NCBI Accession:	P35613.2
UniProt Secondary Accession:	P35613,Q7Z796, Q8IZL7, A6NJW1, D3YLG5,
UniProt Related Accession:	P35613
Molecular Weight:	22,764 Da
NCBI Full Name:	Basigin
NCBI Synonym Full Names:	basigin (Ok blood group)
NCBI Official Symbol:	BSG
NCBI Official Synonym Symbols:	OK; 5F7; TCSF; CD147; EMMPRIN
NCBI Protein Information:	basigin
UniProt Protein Name:	Basigin
UniProt Synonym Protein Names:	5F7; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer; EMMPRIN; Leukocyte activation antigen M6; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor; TCSF; CD_antigen: CD147
Protein Family:	Basigin
UniProt Gene Name:	BSG
UniProt Entry Name:	BASI_HUMAN