The CD14 Polyclonal Antibody (CAB5737) is a vital tool for researchers studying the CD14 protein, a key component in the innate immune response. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications. By binding to the CD14 protein, this antibody allows for the detection and analysis of CD14 in a variety of cell types, making it a valuable resource for investigations in immunology and infectious disease research.CD14 is a co-receptor for bacterial lipopolysaccharide (LPS) and plays a critical role in the recognition and response to microbial pathogens. Its involvement in the inflammatory response makes it a target for understanding the mechanisms of sepsis, a life-threatening condition caused by the body's overwhelming response to infection.
Additionally, CD14 has been implicated in the pathogenesis of various inflammatory diseases, making it a potential therapeutic target for conditions such as sepsis, asthma, and rheumatoid arthritis.By utilizing the CD14 Polyclonal Antibody (CAB5737), researchers can gain valuable insights into the function of CD14 in immunity and inflammation, ultimately contributing to the development of novel therapies for infectious and inflammatory diseases.
Product Name:
CD14 Rabbit Polyclonal Antibody
SKU:
CAB5737
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-330 of human CD14 (NP_000582.1).
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein.
Purification Method:
Affinity purification
Gene ID:
929
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of RAW264.7 cells, using CD14 antibody (CAB5737) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
