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CD14 PAT87H7AT Monoclonal Antibody [PAT87H7AT] (CPAB0343)

SKU:
CPAB0343
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
€149
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Description

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CD14 PAT87H7AT Monoclonal Antibody [PAT87H7AT] (CPAB0343)

The CD14 Monoclonal Antibody (CPAB0343) is a vital tool for researchers studying CD14, a key receptor involved in the recognition of bacterial lipopolysaccharide (LPS) and the activation of immune responses. This antibody is produced from hybridomas and specifically targets human CD14, with validated use in various immunological assays such as Western blotting.CD14 is crucial for the innate immune response, specifically in the detection of pathogen-associated molecular patterns (PAMPs) and the initiation of inflammatory signaling pathways.

By targeting CD14, researchers can investigate the role of this receptor in host defense, sepsis, and other infectious diseases. The antibody's high specificity and sensitivity make it an ideal tool for studying the function and regulation of CD14 in both basic and clinical research settings.

Product Name:CD14 PAT87H7AT Antibody
Product Sku:CPAB0343
Size:5μg
Host Species:Mouse IgG2b
Immunogen:Anti-human CD14 mAb, clone PAT87H7AT, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CD14 protein 2-349 amino acids purified from Ecoli.
Clone:PAT87H7AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:CD14 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:
Background:CD14 (also known lipopolysaccharide (LPS) receptor) is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor for complexes of LPS and LPS binding protein (LBP). Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 has been shown to bind apoptotic cells.
Synonyms:Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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