Anti-CD138 Antibody (FITC) (AGIM0084)

CD138 monoclonal antibody (FITC) (AGIM0084)

SKU:

AGIM0084

Product Type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Host Species:

Mouse

Isotype:

IgG1

Clone:

B-A38

Conjugation:

FITC

Applications:

Description

Description

Datasheet

Isotype:	IgG1
Host Species:	Mouse
Storage:	Store at 4°C. Do not freeze. Avoid prolonged exposure to light.
Uniprot:	P18827
Background:	CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and downregulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.

UniProt Protein Function:	syndecan-1: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Belongs to the syndecan proteoglycan family.
UniProt Protein Details:	Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Extracellular matrix Chromosomal Location of Human Ortholog: 2p24.1 Cellular Component: cell surface; cytoplasm; focal adhesion; Golgi lumen; integral to plasma membrane; lysosomal lumen; plasma membrane Molecular Function:protein binding; protein C-terminus binding Biological Process: cell migration; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; lipoprotein metabolic process; myoblast development; retinoid metabolic process; striated muscle cell development
NCBI Summary:	The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
UniProt Code:	P18827
NCBI GenInfo Identifier:	229463011
NCBI Gene ID:	6382
NCBI Accession:	P18827.3
UniProt Secondary Accession:	P18827,Q53QV0, Q546D3, Q96HB7, D6W523,
UniProt Related Accession:	P18827,AAB21434,AAB23935
Molecular Weight:	32,462 Da
NCBI Full Name:	Syndecan-1
NCBI Synonym Full Names:	syndecan 1
NCBI Official Symbol:	SDC1
NCBI Official Synonym Symbols:	SDC; CD138; SYND1; syndecan
NCBI Protein Information:	syndecan-1
UniProt Protein Name:	Syndecan-1
UniProt Synonym Protein Names:	CD_antigen: CD138
Protein Family:	COMPASS component
UniProt Gene Name:	SDC1
UniProt Entry Name:	SDC1_HUMAN