CD138 monoclonal antibody (FITC) (AGIM0084)
- SKU:
- AGIM0084
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- B-A38
- Conjugation:
- FITC
- Applications:
- FC
Frequently bought together:
Description
system_update_altDatasheet
| Product Name: | CD138 monoclonal antibody (FITC) |
| Product Code: | AGIM0084 |
| Size: | 500 µL |
| Reactivity: | Human |
| Clone: | B-A38 |
| Applications: | Flow Cytometry |
| Conjugate: | FITC |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4°C. Do not freeze. Avoid prolonged exposure to light. |
| Uniprot: | P18827 |
| Background: | CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and downregulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis. |
| UniProt Protein Function: | syndecan-1: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Belongs to the syndecan proteoglycan family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Extracellular matrix Chromosomal Location of Human Ortholog: 2p24.1 Cellular Component: cell surface; cytoplasm; focal adhesion; Golgi lumen; integral to plasma membrane; lysosomal lumen; plasma membrane Molecular Function:protein binding; protein C-terminus binding Biological Process: cell migration; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; lipoprotein metabolic process; myoblast development; retinoid metabolic process; striated muscle cell development |
| NCBI Summary: | The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P18827 |
| NCBI GenInfo Identifier: | 229463011 |
| NCBI Gene ID: | 6382 |
| NCBI Accession: | P18827.3 |
| UniProt Secondary Accession: | P18827,Q53QV0, Q546D3, Q96HB7, D6W523, |
| UniProt Related Accession: | P18827,AAB21434,AAB23935 |
| Molecular Weight: | 32,462 Da |
| NCBI Full Name: | Syndecan-1 |
| NCBI Synonym Full Names: | syndecan 1 |
| NCBI Official Symbol: | SDC1Â Â |
| NCBI Official Synonym Symbols: | SDC; CD138; SYND1; syndecan  |
| NCBI Protein Information: | syndecan-1 |
| UniProt Protein Name: | Syndecan-1 |
| UniProt Synonym Protein Names: | CD_antigen: CD138 |
| Protein Family: | COMPASS component |
| UniProt Gene Name: | SDC1Â Â |
| UniProt Entry Name: | SDC1_HUMAN |
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