CD13/ANPEP Monoclonal Antibody (CAB21268)
- SKU:
- CAB21268
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- IHC
- FC
Description
Product Name: | CD13/ANPEP Monoclonal Antibody |
SKU: | CAB21268 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 69-967 of human CD13/ANPEP (NP_001141.2). |
Sequence: | KAWN RYRL PNTL KPDS YRVT LRPY LTPN DRGL YVFK GSST VRFT CKEA TDVI IIHS KKLN YTLS QGHR VVLR GVGG SQPP DIDK TELV EPTE YLVV HLKG SLVK DSQY EMDS EFEG ELAD DLAG FYRS EYME GNVR KVVA TTQM QAAD ARKS FPCF DEPA MKAE FNIT LIHP KDLT ALSN MLPK GPST PLPE DPNW NVTE FHTT PKMS TYLL AFIV SEFD YVEK QASN GVLI RIWA RPSA IAAG HGDY ALNV TGPI LNFF AGHY DTPY PLPK SDQI GLPD FNAG AMEN WGLV TYRE NSLL FDPL SSSS SNKE RVVT VIAH ELAH QWFG NLVT IEWW NDLW LNEG FASY VEYL GADY AEPT WNLK DLMV LNDV YRVM AVDA LASS HPLS TPAS EINT PAQI SELF DAIS YSKG ASVL RMLS SFLS EDVF KQGL ASYL HTFA YQNT IYLN LWDH LQEA VNNR SIQL PTTV RDIM NRWT LQMG FPVI TVDT STGT LSQE HFLL DPDS NVTR PSEF NYVW IVPI TSIR DGRQ QQDY WLID VRAQ NDLF STSG NEWV LLNL NVTG YYRV NYDE ENWR KIQT QLQR DHSA IPVI NRAQ IIND AFNL ASAH KVPV TLAL NNTL FLIE ERQY MPWE AALS SLSY FKLM FDRS EVYG PMKN YLKK QVTP LFIH FRNN TNNW REIP ENLM DQYS EVNA ISTA CSNG VPEC EEMV SGLF KQWM ENPN NNPI HPNL RSTV YCNA IAQG GEEE WDFA WEQF RNAT LVNE ADKL RAAL ACSK ELWI LNRY LSYT LNPD LIRK QDAT STII SITN NVIG QGLV WDFV QSNW KKLF NDYG GGSF SFSN LIQA VTRR FSTE YELQ QLEQ FKKD NEET GFGS GTRA LEQA LEKT KANI KWVK ENKE VVLQ WFTE NSK |
Tested Applications: | WB IHC-P FC ELISA |
Recommended Dilution: | WB,1:10000 - 1:40000 IHC-P,1:100 - 1:500 FC,1:50 - 1:200 |
Synonyms: | APN; AP-M; AP-N; CD13; LAP1; P150; PEPN; hAPN; GP150; CD13/ANPEP |
Positive Sample: | THP-1 cells |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Single-pass type II membrane protein, cytosol. |
Calculated MW: | 110kDa |
Observed MW: | 160kDa |
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma.
Purification Method: | Affinity purification |
Gene ID: | 290 |
Clone Number: | ARC53706 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |