The CD13 (ANPEP) Monoclonal Antibody (CAB21268) is a valuable tool for research involving CD13, also known as aminopeptidase N (ANPEP). This cell surface molecule plays a role in various physiological processes, including cellular signaling, angiogenesis, and immune response. The antibody, produced using monoclonal technology, shows high specificity and sensitivity for human samples and has been validated for use in a variety of applications, including immunofluorescence and flow cytometry.CD13 is a multifunctional enzyme involved in the metabolism of peptides and plays a critical role in various disease processes, such as cancer progression and viral infections.
Its expression has been linked to tumor invasion and migration, making it a potential diagnostic and therapeutic target in oncology research. The CD13 Monoclonal Antibody enables researchers to study the expression and function of CD13 in different cell types and tissues, providing valuable insights into its biological roles and potential therapeutic applications.
Product Name:
CD13/ANPEP Monoclonal Antibody
SKU:
CAB21268
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 69-967 of human CD13/ANPEP (NP_001141.2).
Cell membrane, Cytoplasm, Single-pass type II membrane protein, cytosol.
Calculated MW:
110kDa
Observed MW:
160kDa
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma.
Purification Method:
Affinity purification
Gene ID:
290
Clone Number:
ARC53706
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD13/ANPEP Rabbit mAb (CAB21268) at1:40000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
