The CD127 (IL-7R) Rabbit Monoclonal Antibody is a powerful tool for researchers studying CD127, also known as the IL-7 receptor, a crucial regulator of immune cell function. This antibody, developed using rabbit monoclonal technology, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for experiments in immunology and cancer research.CD127 is a key component of the IL-7 signaling pathway, essential for the development and survival of T cells, B cells, and natural killer cells. Dysregulation of this pathway has been linked to various immune-related disorders, including cancer and autoimmune diseases. By targeting CD127 with this monoclonal antibody, researchers can effectively detect and study the expression of this receptor in different cell types and understand its role in immune cell development and function.
Validated for use in Western blot applications, the CD127 Rabbit Monoclonal Antibody enables precise detection and analysis of CD127 protein levels, providing valuable insights into potential therapeutic targets for immunotherapy and immunomodulation strategies. By exploring the function of CD127, researchers can further our understanding of immune responses and potentially uncover new treatment options for a range of diseases.
Product Name:
CD127/IL7R Rabbit Monoclonal Antibody
SKU:
CAB11678
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human CD127/IL7R (P16871).
Sequence:
PESF LDCQ IHRV DDIQ ARDE VEGF LQDT FPQQ LEES EKQR LGGD VQSP NCPS EDVV ITPE SFGR DSSL TCLA GNVS ACDA PILS SSRS LDCR ESGK NGPH V
Cell membrane, Secreted, Single-pass type I membrane protein, Single-pass type I membrane protein.
Calculated MW:
52kDa
Observed MW:
72kDa
The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found.
Purification Method:
Affinity purification
Gene ID:
3575
Clone Number:
ARC0672
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CD127/IL7R Rabbit mAb (CAB11678) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
